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  • Iorio C, Rourke JL, Wells, L, Sakamaki J, Moon E, Hu Q, Kin T, Screaton, RA. Silencing the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway Promotes Human β Cell Proliferation. bioRxiv. (2021). Preprint
  • Wells L, Iorio C, Ng AC-H, Reeks C, Yee S-P, Screaton RA. ROMO1 is essential for glucose coupling in the pancreatic beta cell in male mice. bioRxiv. (2021). Preprint
  • Iorio, C, Buzina, A., Jerzak, KJ, Andrews DW, Screaton, RA. RNAi screening in primary human breast biopsies identifies mitochondrial glutamate flux as a metabolic vulnerability in locally advanced breast cancer. Research Square. (2021). Preprint
  • Estall JL and Screaton RA. Of Mice and Men, Redux: Modern Challenges in β Cell Gene Targeting. Invited Review. Endocrinology. (2020). PubMed 
  • Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ. The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC. Cancer Discovery. (2019). PubMed
  • Lam WW, Oakden W, Murray L, Klein J, Iorio C, Screaton RA, Koletar MM, Chu W, Liu SK, Stanisz GJ. Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI. Scientific  Reports. (2018). PubMed
     
  • Patra KC, Kato Y, Mizukami Y, Widholz S, Myriam B, Revenco J, Grossman EA, Ji F, Ruslan SI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N. Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nature Cell Biology. (2018). PubMed 
     
  • Rourke JL, Hu Q, Screaton RA. AMPK and friends: Central Regulators of Beta Cell Biology. Invited Review. Trends Endo Metab. (2018). PubMed
  • Sabouny R, Fraunberger E, Geoffrion M, Ng AC, Baird SD, Screaton RA, Milne R, McBride HM, Shutt TE. The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Antioxid Redox Signal. (2017).   PubMed
  • Cogger KF, Sarangi ASF, McGaugh E, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke, JL, Screaton RA, Grompe M, Streeter PR, Powers A, Brissova M, Kislinger T, Nostro MC. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nature Communications. (2017). PubMed  
  • Li YJ, Sun L, Shi Y, Wang G, Wang X, Dunn SE, Iorio C, Screaton RA, Spaner DE. PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions. Leukemia. (2017).   PubMed
  • Robitaille K, Rourke JL, McBane JE, Fu A, Baird S, Du Q, Kin T, Shapiro AM, Screaton RA. High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. J Biol Chem. (2016).   PubMed
  • Reeks C, Screaton RA. Identification of Kinase-substrate Pairs Using High Throughput Screening. J Vis Exp. (2015).   PubMed
  • Courteau L, Crasto J, Hassanzadeh G, Baird SD, Hodgins J, Liwak-Nuir U, Fung G, Luo H, Stojdl DF, Screaton RA, Holcik M. Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein. Cell Death Dis. (2015).   PubMed
  • Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, Screaton RA, Poitout V, Ferron M, Alquier T, Estall JL. Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone. Diabetes. (2015).   PubMed
  • Estall JL, Screaton RA. To Be(ta Cell) or Not to Be(ta cell): New Mouse Models for Studying Gene Function in the Pancreatic ß-cell. Endocrinology. (2015).   PubMed
  • Sawyer SL, Cheuk-Him Ng A, Innes AM, Wagner JD, Dyment DA, Tetreault M; Care4Rare Canada Consortium, Majewski J, Boycott KM, Screaton RA, Nicholson G. Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy. Hum Mol Genet. (2015).  PubMed
  • Fu, A., Robitaille, K., Faubert, B., Reeks, C., Dai, X-Q., Hardy, A.B., Sankar, K.S., Ogrel, S.,  Al-Dirbashi, O.Y., Rocheleau, J.V., Wheeler, M.B., MacDonald, P.E., Jones, R. and Screaton R.A. LKB1 couples glucose metabolism to insulin secretion. Diabetologia. (2015).  PubMed

  • Ng, A.C., Baird, S.D. and Screaton R.A. High-content functional genomic screening to identify novel regulators of the PINK1-Parkin pathway. Methods Enzymol. 547: 1-20 (2014).  PubMed
  • Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R.A., Gratton, J-P., and Côté, J-F. Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion. Molecular and Cellular Biology (2014).  PubMed
  • Norton, M. and Screaton, R.A. SGK1: master and commander of the fate of helper T cells. Nature Immunology 15: 411-3 (2014).  PubMed
  • Norton, M., Ng, A. C-H., Baird, S., Dumoulin, A., Shutt, T., Mah, N., Andrade-Navarro, M., McBride, H.M. and Screaton, R.A. Genome-wide RNAi screen identifies Romo1 as essential redox-dependent regulator of mitochondrial dynamics. Science Signaling 28(7): 310-18 (2014). PubMed    Editor's Summary    Full Text    Perspectives   
  • Ng, A. C-H., Baird, S. and Screaton, R.A. Role of TID1 in the regulation of mitochondrial membrane potential and the maintenance of mitochondrial DNA. Molecular and Cellular Biology (2014). PubMed
  • Lefebvre, V., Du, Q., Ng, A., Baird, S., Nascimento, M., Campanella, M., McBride, H. and Screaton, R.A. Genome-wide RNAi screen identifies ATPase Inhibitory Factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy. Autophagy 9(11): 1770-9 (2013). PubMed
  • Eberhard, C.E., Fu, A., Reeks, C. and Screaton, R.A. CRTC2 is required for beta cell function and proliferation. Endocrinology 154(7): 2308-17 (2013). PubMed
  • Germain, M., Nguyen, A.P., Khacho, M., Patten, D.A., Screaton, R.A., Park, D.S. and Slack, R.S. LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Hum Mol Genet 22(5): 952-62 (2013). PubMed
  • Fu, A., Eberhard, C.E. and Screaton, R.A. Role of AMPK in the Beta Cell. Invited Review. Molecular and Cellular Endocrinology 366(2): 127-34 (2013). PubMed

  • Wang, Y., Li, G., Paz, J.C., Screaton, R., Fischer, W.H., Tabas, I., and Montminy, M. Inositol 1,4,5-trisphosphate Receptor Regulates Fasting Hepatic Gluconeogenesis. Nature 485: 128-32 (2012). PubMed

  • Bowerman, M., Michalski, J-P., Wang, G-S., Reeks, C., Beauvais, A., Murphy, K., Woulfe, J., Swoboda, K.J., Screaton, R.A., Scott, F.W. and Kothary, R. Glucose Metabolism And Pancreatic Defects In Spinal Muscular Atrophy. Annals of Neurology 72(2): 256-62 (2012).  PubMed

  • Fu, A., Ng, A. C-H., Depatie, C., Wijesekara, N., He, Y. Wang, G-S., Bardeesy, N., Scott, F.W., Touyz, R.M., Wheeler, M.B. and Screaton, R.A. Loss of Lkb1 in adult β cells increases β cell mass and enhances glucose tolerance in mice. Cell Metabolism 10: 285-95 (2009). PubMed
  • Fu, A. and Screaton, R.A. Using Kinomics to Delineate Signaling Pathways: Control of CRTC2/TORC2 by the AMPK Family. Cell Cycle 7(24): 3823-8 (2008). PubMed
  • Jansson, D., Ng, A. C-H, Fu, A., Depatie, C., Al Azzabi, M. and Screaton, R.A. Glucose Controls CREB Activity in Islet Cells via Regulated Phosphorylation of TORC2. PNAS 105: 10161-10166 (2008). PubMed
  • Qi, L., Heredia, J., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., MacLeod, I.X., Liew, C.W., Kulkarni, R., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J. and Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312: 1763-66 (2006). PubMed
  • Koo, S-H, Flechner, L., Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H. and Montminy, M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109-11 (2005). PubMed

  • Screaton R.A., Conkright, M.D., Katoh, Y., Best, J., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J.R. III, Takemori, H., Okamoto, M. and Montminy, M. The CREB Coactivator TORC2 Functions as a Calcium and cAMP Sensitive Coincidence Detector. Cell 119: 61-74 (2004). PubMed
  • Conkright, M.D., Canettieri, G., Screaton, R., Guzman, E., Miraglia, L., Hogenesch, J., and Montminy, M. TORCs: Novel Transducers of Regulated CREB Activity. Mol. Cell 12: 413-23 (2003). PubMed
  • Jhala, U., Canettieri, G., Screaton, R.A., Kulkarni, R.N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M. and Montminy, M. cAMP Promotes Pancreatic Beta Cell Survival via CREB Mediated Induction of IRS2. Genes Dev. 15: 1575-80 (2003). PubMed

 

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